D-Lysergic acid N,N-diethylamide

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CAS: 50-37-3
MF: C20H25N3O
MW: 323.432
Synonyms: D-Lysergic acid N,N-diethylamide

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Sabre Kais

Purdue University
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Piero R. Gardinali

Florida International University
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Jeffery G. Saven

University of Pennsylvania
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Thomas E. Prisinzano

The University of Kansas
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Sarah Trimpin

Wayne State University
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Co-reporter: Daniel W. Woodall, Beixi Wang, Ellen D. Inutan, Srinivas B. Narayan, and Sarah Trimpin
pp: 4667
Publication Date(Web):March 10, 2015
DOI: 10.1021/ac504475x
Matrix assisted ionization vacuum (MAIV) rapidly generates gas-phase analyte ions from subliming solid-phase matrix:analyte crystals for analysis by mass spectrometry (MS). Ionization from the solid-phase allows the use of a variety of surfaces for introducing matrix:analyte samples to the vacuum of a mass spectrometer, including common laboratory materials, such as disposable pipet tips, filter paper, tooth picks, and nylon mesh. MAIV is shown here to be capable of analyses as fast as 3 s per sample with achievable sensitivities in the low femtomole range. MAIV-MS coupled with ion mobility spectrometry (IMS)-MS and tandem mass spectrometry (MS/MS) is shown to be especially powerful for analysis and characterization of a wide range of molecules ranging from small molecules such as drugs and metabolites (∼300 Da) to intact proteins (25.6 kDa). Automated sample introduction is demonstrated on two different commercial mass spectrometers using a programmable XYZ stage. A MAIV high-throughput nontargeted MSE approach is also demonstrated utilizing IMS for rapid characterization of small molecules and peptides from standard solutions, as well as drug spiked human urine.

Raymond C. Stevens

The Scripps Research Institute
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J. Gregor Sutcliffe

The Scripps Research Institute
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Mirek Macka

Dublin City University
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Brett Paull

Dublin City University
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Omar K. Farha

Northwestern University
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