Shigenobu Yonemura

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Organization: Riken , Japan
Department:
Title: (PhD)
Co-reporter:Shigenobu Yonemura
Current Opinion in Cell Biology (October 2011) Volume 23(Issue 5) pp:515-522
Publication Date(Web):1 October 2011
DOI:10.1016/j.ceb.2011.07.001
The adherens junction (AJ) is a major cell–cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place through cell adhesion. Through the efforts to understand embryonic or cellular morphogenesis, dynamic interactions between the AJ and actin filaments have become crucial issues to be addressed since actin association is essential for AJ development, remodeling and function. Here, I provide an overview of cadherin–actin interaction from morphological aspects and of possible molecular mechanisms revealed by recent studies.Highlights► Cadherin–actin interactions at adherens junctions (AJ) are overviewed. ► There are three types of AJs judging from the mode of actin association. ► Proteins involved in actin dynamics or actin binding at AJ are discussed. ► Recent work revealed the importance of α-catenin in the cadherin–actin linkage.
Glycinamide, L-lysyl-L-arginyl-L-arginyl-L-tryptophyl-L-lysyl-L-lysyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-valyl-L-seryl-L-alanyl-L-alanyl-L-alanyl-L-arginyl-L-phenylalanyl-
Luteinizing hormone
Thyrotropin
1H-1,4-Diazepine,hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-
6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile
Y-27632
Novel protein kinase C