2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE

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CAS: 37578-06-6
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Synonyms: 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE

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Yanlong Gu

Huazhong University of Science and Technology
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Co-reporter: Rongxian Bai, Ping Liu, Jian Yang, Changhui Liu, and Yanlong Gu
pp: 1292
Publication Date(Web):May 11, 2015
DOI: 10.1021/sc500763q
Substituted 2-aminothiophenes were synthesized through Gewald reaction by using an easily available solid base catalyst, sodium aluminate. Cost-effectiveness, mild and environmentally benign conditions, and excellent catalytic performance are the features of this system. Furthermore, the NaAlO2 catalyst can be swimmingly recovered and reused in this reaction.Keywords: 2-Aminothiophenes; Gewald reaction; Multicomponent reaction; NaAlO2

RongXian Bai

Huazhong University of Science and Technology
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Bo Li

China Pharmaceutical University
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