Co-reporter: Liwei Zou, Baomin Wang, Hongfang Mu, Huanrui Zhang, Yuming Song, and Jingping Qu
pp: 3106-3109
Publication Date(Web):June 11, 2013
DOI: 10.1021/ol401306h
A novel library of chiral guanidines featuring a tartaric acid skeleton was developed from diethyl l-tartrate. These guanidines are easily accessed with tunable steric and electronic properties. The utilities of the guanidines were highlighted by their ability to catalyze the α-hydroxylation of β-ketoesters and β-diketones with remarkable efficiency and excellent enantioselectivity.
