Benzenemethanol, 4-chloro-a-methyl-a-(phenylethynyl)-

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CAS: 800369-10-2
MF: C16H13ClO
MW:
Synonyms: Benzenemethanol, 4-chloro-a-methyl-a-(phenylethynyl)-

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Ling Song

Chinese Academy of Sciences
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Co-reporter: Junfeng Liu, Jin Lin, Ling Song
pp: 2160-2163
Publication Date(Web):25 April 2012
DOI: 10.1016/j.tetlet.2012.02.058
A mild, efficient, and transition-metal-free method for nucleophilic addition of arylacetylenes to diverse aromatic ketones, using catalytic amount of tetrabutylammonium chloride as a promoter and solid KOH as a base in THF, was developed to afford aromatic tertiary propargylic alcohols with high and excellent yields. Aliphatic ketones also gave satisfactory results.Image for unlabelled figure

Shufeng Chen

Inner Mongolia University
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Haiying Zhao

Inner Mongolia University
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