Co-reporter: Xiang Chen, Zheng-Hang Qi, Shao-Yun Zhang, Ling-Pei Kong, Yong Wang, and Xing-Wang Wang
pp: 42-45
Publication Date(Web):December 17, 2014
DOI: 10.1021/ol503210q
A formal thio [3 + 3]-cyclization catalyzed by a DPEN-derived chiral thiourea has been reported for the construction of optically active thiopyrano-indole annulated heterocyclic compounds in high yields with excellent enantioselectivities. The high reactivity between indoline-2-thione (keto-S) and 2-benzylidenemalononitrile has also been supported by density functional theory (DFT) calculations.
