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Fei Nie

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Name: 聂菲
Organization: Northwest University , China
Department: Institute of Analytical Science
Title: NULL(PhD)

TOPICS

An ultrasensitive chemiluminescent method for the tanshinol borneol ester determination and its pharmacokinetic analysis
Co-reporter:Fei Nie;Min Bu;Lihong Wu ;Jianbin Zheng
Luminescence 2014 Volume 29( Issue 2) pp:147-150
Publication Date(Web):
DOI:10.1002/bio.2519

ABSTRACT

Tanshinol borneol ester (DBZ), a chemical combination of danshensu and borneol, is an experimental drug that exhibits efficacious anti-ischemic activity in animal models. In this work, an ultrasensitive chemiluminescence (CL) method for the determination of DBZ was established based on the inhibitory effect of DBZ on the CL signal produced from the reaction between potassium permanganate and luminol in alkaline solution. The CL intensity responded linearly to the concentration of DBZ in the range 2.0 × 10-10 to 4.0 × 10-8 g/mL with a detection limit of 7 × 10−11 g/mL. The relative standard deviation (RSD) was 3.8% for 4.0 × 10−9 g DBZ (n = 11). The proposed method showed characteristics of high sensitivity, simple device and quick. In addition, this proposed method had been applied satisfactorily to the analysis of DBZ in blood. The pharmacokinetics of DBZ in rat has also been studied using the CL method. Copyright © 2013 John Wiley & Sons, Ltd.

An ultrasensitive post chemiluminescence reaction of ammonium in NBS–dichlorofluorescein system and its application
Co-reporter:Fei Nie, Na Wang, Jianbin Zheng, Juncai Zhang
Talanta 2011 Volume 84(Issue 4) pp:1063-1067
Publication Date(Web):30 May 2011
DOI:10.1016/j.talanta.2011.03.005
A strong post chemiluminescence (PCL) phenomenon was observed when ammonium was injected into the reaction mixture after the finish of CL reaction of N-bromosuccinimide (NBS) and dichlorofluorescein. Based on this, a sensitive flow injection PCL method was established for the determination of ammonium. The possible CL mechanism of the reaction was proposed based on a series of experiments. The PCL intensity responded linearly to the concentration of ammonium in the range 3.0 × 10−11–1.0 × 10−7 g mL−1 with a detection limit of 1 × 10−11 g mL−1. The relative standard deviation (R.S.D.) was 1.4% for 1.0 × 10−9 g mL−1 ammonium (n = 11). This method had been applied to the determination of ammonium in samples of mineral water, tap water and river water.
Triprolidine Hydrochloride
Triprolidine Hydrochloride
CAS:550-70-9
Triprolidine Hydrochloride
(1R,2S)-(-)-Ephedrine hydrochloride
(1R,2S)-(-)-Ephedrine hydrochloride
CAS:50-98-6
(1R,2S)-(-)-Ephedrine hydrochloride