Prof.Pinhua Li - Cochemist

Photoinduced difunctionalization of 2,3-dihydrofuran for the efficient synthesis of 2,3-disubstituted tetrahydrofurans

Co-reporter:Xingxing Zhu;Man-Yi Han;Pinhua Li;Lei Wang

Organic Chemistry Frontiers 2017 vol. 4(Issue 8) pp:1640-1646

Publication Date(Web):2017/07/26

DOI:10.1039/C7QO00242D

A highly efficient photoinduced multicomponent difunctionalization of 2,3-dihydrofuran has been developed for the synthesis of 2,3-disubstituted tetrahydrofurans under mild reaction conditions. Compared to the previous procedures, the new regioselectivity of the olefin in 2,3-dihydrofuran is disclosed. Moreover, a wide range of functional groups were tolerated and the corresponding products were obtained in high yields.

Visible light-induced tandem oxidative cyclization of 2-alkynylanilines with disulfides (diselenides) to 3-sulfenyl- and 3-selenylindoles under transition metal-free and photocatalyst-free conditions

Co-reporter:Qing Shi;Pinhua Li;Yan Zhang;Lei Wang

Organic Chemistry Frontiers 2017 vol. 4(Issue 7) pp:1322-1330

Publication Date(Web):2017/06/27

DOI:10.1039/C7QO00152E

A simple and efficient strategy for the synthesis of 3-sulfenyl and 3-selenyl indoles via a visible light-induced tandem cyclization of 2-alkynylanilines with disulfides (diselenides) was developed. The reaction generated the corresponding products in good yields at room temperature under transition metal-free and photocatalyst-free conditions.

Visible-light-induced tandem cyclization of 2-alkynylanilines with disulfides: a convenient method for accessing benzothiophenes under transition-metal-free and photocatalyst-free conditions

Co-reporter:Xiaoyu Xie;Pinhua Li;Qing Shi;Lei Wang

Organic & Biomolecular Chemistry 2017 vol. 15(Issue 36) pp:7678-7684

Publication Date(Web):2017/09/20

DOI:10.1039/C7OB01747B

A simple and efficient strategy for the preparation of benzothiophenes via visible-light-induced cyclization of 2-alkynylanilines with disulfides was developed. The reaction afforded the desired products in good yields at room temperature under transition-metal-free and photocatalyst-free conditions.

Visible-light-induced and iron-catalyzed methylation of N-arylacrylamides with dimethyl sulphoxide: a convenient access to 3-ethyl-3-methyl oxindoles

Co-reporter:Zuguang Xie;Pinhua Li;Yu Hu;Ning Xu;Lei Wang

Organic & Biomolecular Chemistry 2017 vol. 15(Issue 19) pp:4205-4211

Publication Date(Web):2017/05/16

DOI:10.1039/C7OB00779E

A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulphoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as methoxy, trifluoromethyl, cyano, nitro, acetyl and ethyloxy carbonyl groups. The visible-light promoted radical methylation and arylation of the alkenyl group are involved in this reaction.

Visible-Light-Induced Direct Thiolation at α-C(sp3)–H of Ethers with Disulfides Using Acridine Red as Photocatalyst

Co-reporter:Xianjin Zhu, Xiaoyu Xie, Pinhua Li, Jianqi Guo, and Lei Wang

Organic Letters 2016 Volume 18(Issue 7) pp:1546-1549

Publication Date(Web):March 22, 2016

DOI:10.1021/acs.orglett.6b00304

A simple and efficient method for the preparation of α-arylthioethers through a visible-light-induced direct thiolation at α-C(sp3)–H of ethers with diaryl disulfides was developed using acridine red as a novel photocatalyst. The reactions occurred at ambient conditions and generated the corresponding products in good to excellent yields, ignoring steric effect of disulfides.

Nickel-Catalyzed Site-Selective C–H Bond Difluoroalkylation of 8-Aminoquinolines on the C5-Position

Co-reporter:Hao Chen, Pinhua Li, Min Wang, and Lei Wang

Organic Letters 2016 Volume 18(Issue 19) pp:4794-4797

Publication Date(Web):September 9, 2016

DOI:10.1021/acs.orglett.6b02166

A simple and efficient protocol for nickel-catalyzed regioselective C–H bond difluoroalkylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides was developed. The reaction has broad substrate scope and provides a facile and useful access to the corresponding C5-functionalized difluoromethylated quinolines in good to excellent yields.

Merging Photoredox with Palladium Catalysis: Decarboxylative ortho-Acylation of Acetanilides with α-Oxocarboxylic Acids under Mild Reaction Conditions

Co-reporter:Chao Zhou, Pinhua Li, Xianjin Zhu, and Lei Wang

Organic Letters 2015 Volume 17(Issue 24) pp:6198-6201

Publication Date(Web):December 8, 2015

DOI:10.1021/acs.orglett.5b03192

A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y with Pd dual catalytic system. This dual catalytic reaction shows a broad substrate scope and good functional group tolerance, and an array of ortho-acylacetanilides can be afforded in high yields under mild conditions.

Palladium Supported on Magnetic CoreShell Nanoparticles: An Efficient and Reusable Catalyst for the Oxidation of Alcohols into Aldehydes and Ketones by Molecular Oxygen

Co-reporter:Lei Zhang; Pinhua Li;Dr. Jin Yang;Dr. Min Wang; Lei Wang

ChemPlusChem 2014 Volume 79( Issue 2) pp:217-222

Publication Date(Web):

DOI:10.1002/cplu.201300353

Abstract

In continuing our efforts to develop economical and ecofriendly synthetic protocols, we present a proline–palladium catalyst supported on magnetic nanoparticles (0.5 mol %) for oxidation by molecular oxygen. The supported Pd catalyst shows high activity in the oxidation of alcohols into the corresponding carbonyl compounds where easy catalyst recovery and excellent recycling efficiency are observed. It is possible to recover and reuse the grafted palladium catalysts at least eight times without significant loss of its catalytic activity.

Visible-light-induced and iron-catalyzed methylation of N-arylacrylamides with dimethyl sulphoxide: a convenient access to 3-ethyl-3-methyl oxindoles

Co-reporter:Zuguang Xie, Pinhua Li, Yu Hu, Ning Xu and Lei Wang

Organic & Biomolecular Chemistry 2017 - vol. 15(Issue 19) pp:NaN4211-4211

Publication Date(Web):2017/04/20

DOI:10.1039/C7OB00779E

A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulphoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as methoxy, trifluoromethyl, cyano, nitro, acetyl and ethyloxy carbonyl groups. The visible-light promoted radical methylation and arylation of the alkenyl group are involved in this reaction.

Photoinduced difunctionalization of 2,3-dihydrofuran for the efficient synthesis of 2,3-disubstituted tetrahydrofurans

Co-reporter:Xingxing Zhu, Man-Yi Han, Pinhua Li and Lei Wang

Inorganic Chemistry Frontiers 2017 - vol. 4(Issue 8) pp:NaN1646-1646

Publication Date(Web):2017/05/19

DOI:10.1039/C7QO00242D

A highly efficient photoinduced multicomponent difunctionalization of 2,3-dihydrofuran has been developed for the synthesis of 2,3-disubstituted tetrahydrofurans under mild reaction conditions. Compared to the previous procedures, the new regioselectivity of the olefin in 2,3-dihydrofuran is disclosed. Moreover, a wide range of functional groups were tolerated and the corresponding products were obtained in high yields.

Visible light-induced tandem oxidative cyclization of 2-alkynylanilines with disulfides (diselenides) to 3-sulfenyl- and 3-selenylindoles under transition metal-free and photocatalyst-free conditions

Co-reporter:Qing Shi, Pinhua Li, Yan Zhang and Lei Wang

Inorganic Chemistry Frontiers 2017 - vol. 4(Issue 7) pp:

Publication Date(Web):

DOI:10.1039/C7QO00152E