Co-reporter:Kaori Taniguchi;Dr. Shinya Takizawa;Dr. Tomoya Hirano; Shigeru Murata; Hiroyuki Kagechika; Akio Kishida;Dr. Ayumi Ohsaki
ChemPlusChem 2012 Volume 77( Issue 6) pp:427-431
Publication Date(Web):
DOI:10.1002/cplu.201200016
Co-reporter:Ayumi Ohsaki, Shunsuke Kawamata, Masaaki Ozawa, Akio Kishida, Xun Gong, Chiaki Kuroda
Tetrahedron Letters 2011 Volume 52(Issue 12) pp:1375-1377
Publication Date(Web):23 March 2011
DOI:10.1016/j.tetlet.2011.01.080
A novel compound, named salviskinone A (1), was isolated from Salvia przewarskii. The compound has a rearranged carbon skeleton with a methyl unit at C-5 from abietane-type diterpene. Its structure and relative stereochemistry were elucidated by detailed spectroscopic analysis, including HREIMS and 2DNMR (COSY, HSQC, HMBC, and NOESY) spectra.
Co-reporter:Masaaki Ozawa, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Akio Kishida, Ayumi Ohsaki
Bioorganic & Medicinal Chemistry Letters 2009 Volume 19(Issue 1) pp:234-236
Publication Date(Web):1 January 2009
DOI:10.1016/j.bmcl.2008.10.111
A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2–7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2–7, 9) and an indole alkaloid (8). The new compound (1) was elucidated by spectroscopic methods. Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.
Co-reporter:Ayumi Ohsaki, Takashi Nagaoka, Kaisuke Yoneda, Akio Kishida
Tetrahedron Letters 2009 50(50) pp: 6965-6967
Publication Date(Web):
DOI:10.1016/j.tetlet.2009.09.138
Co-reporter:Ayumi Ohsaki, Yukino Kobayashi, Kaisuke Yoneda, Akio Kishida and Haruaki Ishiyama
Journal of Natural Products 2007 Volume 70(Issue 12) pp:2003-2005
Publication Date(Web):December 1, 2007
DOI:10.1021/np0780102
Three new Securinega alkaloids, secu’amamines B−D (1–3), were isolated from the wood of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five known analogues (4, 6–9). The structures 1−3 were elucidated by spectroscopic methods including 2D NMR, and all eight compounds were evaluated for cytotoxicity against two cancer cell lines.