Co-reporter:Xin Li, Xiao-Ming Li, Gang-Ming Xu, Chun-Shun Li, Bin-Gui Wang
Phytochemistry Letters 2014 7() pp: 120-123
Publication Date(Web):
DOI:10.1016/j.phytol.2013.11.008
Co-reporter:Xin Li, Xiao-Ming Li, Gang-Ming Xu, Chun-Shun Li, Bin-Gui Wang
Phytochemistry Letters (February 2014) Volume 7() pp:120-123
Publication Date(Web):1 February 2014
DOI:10.1016/j.phytol.2013.11.008
•Metabolites of the marine alga-derived endophytic fungus Aspergillus wentii EN-48 were investigated.•A new seco-anthraquinone and a new benzamide derivative were obtained.•Compounds 2–8 exhibited significant scavenging activity against DPPH.Eight secondary metabolites (1–8) including a new seco-anthraquinone (wentiquinone C, 1) and a new benzamide derivative (methyl 4-(3,4-dihydroxybenzamido)butanoate, 2), as well as three other derivatives (4, 7, and 8) that were isolated from natural source for the first time, were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Aspergillus wentii EN-48. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR experiments. Each of the isolated compounds was evaluated for α,α-diphenyl-picrylhydrazyl (DPPH) radical scavenging activity, and some of them showed potent activities with IC50 values ranging from 5.2 to 99.4 μg/mL, compared to the positive control, butylated hydroxytoluene (BHT), with an IC50 of 36.9 μg/mL.Download full-size image