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Ren-wang Jiang

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Organization: Jinan University
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Title:
Antiviral Constituents against Respiratory Viruses from Mikania micrantha
Co-reporter:Paul Pui-Hay But, Zhen-Dan He, Shuang-Cheng Ma, Yiu-Man Chan, Pang-Chui Shaw, Wen-Cai Ye and Ren-Wang Jiang
Journal of Natural Products 2009 Volume 72(Issue 5) pp:925-928
Publication Date(Web):March 6, 2009
DOI:10.1021/np800542t
Phytochemical investigation of the dried aerial parts of Mikania micrantha led to the isolation of a new sesquiterpene, 3β-acetoxy-1,10-epoxy-4-germacrene-12,8;15,6-diolide (1), along with six known constituents: 1,10-epoxy-4-germacrene-12,8;15,6-diolide (2), dihydromikanolide (3), potassium mikanin 3-sulfate (4), mikanin (5), alpinetin (6), and ergosta-7,22-dien-3β-ol (7). Their structures were elucidated by spectroscopic methods, and the molecular structures and stereochemistry of sesquiterpene lactones 1−3 were revealed by single-crystal X-ray analysis. Compound 2 showed moderate activity against respiratory syncytial virus (IC50 = 37.4 uM) and parainfluenza type 3 virus (IC50 = 37.4 uM) with a therapeutic index (TI) of 16.0 for both compounds. Compound 4, the main component of M. micrantha, exhibited inhibitory activity against parainfluenza type 3 virus with IC50 (19.7 uM) and TI (24.0) values comparable to those of ribavirin, serving as a positive control.
Caesalpine B
Caesalpine B
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Caesalpine B
Caesalpine A
Caesalpine A
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Caesalpine A
12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-oleandropyranosyl-(1->4)-beta-D-digitoxopyranoside
12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-oleandropyranosyl-(1->4)-beta-D-digitoxopyranoside
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12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-oleandropyranosyl-(1->4)-beta-D-digitoxopyranoside
(1S,4aR,6S,6aS,11aS,11bS)-4a,6-dihydroxy-4,4,11b-trimethyl-7-oxo-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-1-yl acetate
(1S,4aR,6S,6aS,11aS,11bS)-4a,6-dihydroxy-4,4,11b-trimethyl-7-oxo-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-1-yl acetate
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(1S,4aR,6S,6aS,11aS,11bS)-4a,6-dihydroxy-4,4,11b-trimethyl-7-oxo-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-1-yl acetate
ETHANONE, 1-[2-[1,2-DIHYDROXY-1-(HYDROXYMETHYL)ETHYL]-5-HYDROXY-6-BENZOFURANYL]-
ETHANONE, 1-[2-[1,2-DIHYDROXY-1-(HYDROXYMETHYL)ETHYL]-5-HYDROXY-6-BENZOFURANYL]-
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ETHANONE, 1-[2-[1,2-DIHYDROXY-1-(HYDROXYMETHYL)ETHYL]-5-HYDROXY-6-BENZOFURANYL]-
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Caesalmin E
Caesalmin E
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Caesalmin E
Ethanone, 1-[2-(1,2-dihydroxy-1-methylethyl)-5-benzofuranyl]-
Ethanone, 1-[2-(1,2-dihydroxy-1-methylethyl)-5-benzofuranyl]-
CAS:200860-97-5
Ethanone, 1-[2-(1,2-dihydroxy-1-methylethyl)-5-benzofuranyl]-
(3bS,3b<sup>1</sup>R,5aR,6S,6aR,10S,10aS,10bS)-6a,10-dihydroxy-7,7,10a-trimethyl-4-oxo-3b,3b<sup>1</sup>,5a,6,6a,7,8,9,10,10a,10b,11-dodecahydro-4H-phenanthro[3,2-b:10,1-b'c']difuran-6-yl acetate
(3bS,3b<sup>1</sup>R,5aR,6S,6aR,10S,10aS,10bS)-6a,10-dihydroxy-7,7,10a-trimethyl-4-oxo-3b,3b<sup>1</sup>,5a,6,6a,7,8,9,10,10a,10b,11-dodecahydro-4H-phenanthro[3,2-b:10,1-b'c']difuran-6-yl acetate
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(3bS,3b1R,5aR,6S,6aR,10S,10aS,10bS)-6a,10-dihydroxy-7,7,10a-trimethyl-4-oxo-3b,3b1,5a,6,6a,7,8,9,10,10a,10b,11-dodecahydro-4H-phenanthro[3,2-b:10,1-b'c']difuran-6-yl acetate
methyl (1S,4aR,6S,6aR,7S,11aS,11bS)-1-acetoxy-4a,6-dihydroxy-4,4,11b-trimethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-7-carboxylate
methyl (1S,4aR,6S,6aR,7S,11aS,11bS)-1-acetoxy-4a,6-dihydroxy-4,4,11b-trimethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-7-carboxylate
CAS:197781-84-3
methyl (1S,4aR,6S,6aR,7S,11aS,11bS)-1-acetoxy-4a,6-dihydroxy-4,4,11b-trimethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-7-carboxylate