A novel cobalt-free perovskite oxide Ba0.5Sr0.5Fe0.8Cu0.2O3−δ (BSFC) is employed as a cathode material for intermediate-temperature solid oxide fuel cells (IT-SOFCs). The electrical conductivity of BSFC reaches the maximum value of 57 S cm−1 at 600 °C. Symmetrical electrochemical cell with the configuration of BSFC/SDC/BSFC is applied for the impedance study and area specific resistance (ASR) of BSFC cathode material is as low as 0.137 Ω cm2 at 700 °C. The single cell, consisting of BSFC/SDC/NiO–SDC structure, is assembled and tested from 550 to 700 °C with humidified hydrogen (∼3% H2O) as the fuel and the static air as the oxidant. A maximum power density of 718 mW cm2 is obtained at 700 °C for the single cell. Preliminary results demonstrate that the cobalt-free oxide BSFC is a very promising cathode material for application in IT-SOFCs.