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Gary L. Grunewald

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Name: Grunewald, Gary
Organization: University of Kansas , USA
Department: Department of Medicinal Chemistry
Title: Professor(PhD)
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines
Co-reporter:Gary L. Grunewald, F. Anthony Romero, Mitchell R. Seim, Kevin R. Criscione, Jean D. Deupree, Christy C. Spackman, David B. Bylund
Bioorganic & Medicinal Chemistry Letters 2005 Volume 15(Issue 4) pp:1143-1147
Publication Date(Web):15 February 2005
DOI:10.1016/j.bmcl.2004.12.013
3-Hydroxyethyl- and 3-hydroxypropyl-7-substituted-tetrahydroisoquinolines (9, 10, 16, and 17) were synthesized and evaluated for their phenylethanolamine N-methyltransferase (PNMT) inhibitory potency and affinity for the α2-adrenoceptor. Although α2-adrenoceptor affinity decreased for these compounds, selectivity was not gained over the parent 3-hydroxymethyl compounds (1, 2) due to a loss in PNMT inhibitory potency.
1H-INDENE-1-CARBOXYLICACID,2,3-DIHYDRO-3-(HYDROXYIMINO)-,METHYLESTER,(Z)-(9CI)
1H-INDENE-1-CARBOXYLICACID,2,3-DIHYDRO-3-(HYDROXYIMINO)-,METHYLESTER,(Z)-(9CI)
CAS:111634-92-5
1H-INDENE-1-CARBOXYLICACID,2,3-DIHYDRO-3-(HYDROXYIMINO)-,METHYLESTER,(Z)-(9CI)
1H-Indene-1-carboxylic acid, 2,3-dihydro-3-(hydroxyimino)-, methyl ester, (E)-
1H-Indene-1-carboxylic acid, 2,3-dihydro-3-(hydroxyimino)-, methyl ester, (E)-
CAS:111634-90-3
1H-Indene-1-carboxylic acid, 2,3-dihydro-3-(hydroxyimino)-, methyl ester, (E)-
1,4-Methanoisoquinoline, 1,2,3,4-tetrahydro-
1,4-Methanoisoquinoline, 1,2,3,4-tetrahydro-
CAS:111634-88-9
1,4-Methanoisoquinoline, 1,2,3,4-tetrahydro-
1,4-Ethanoisoquinoline, 1,2,3,4-tetrahydro-, hydrochloride
1,4-Ethanoisoquinoline, 1,2,3,4-tetrahydro-, hydrochloride
CAS:111634-86-7
1,4-Ethanoisoquinoline, 1,2,3,4-tetrahydro-, hydrochloride
4-Methyl-1,2,3,4-tetrahydroisoquinoline
4-Methyl-1,2,3,4-tetrahydroisoquinoline
CAS:110841-71-9
4-Methyl-1,2,3,4-tetrahydroisoquinoline
9H-Fluorene-1-methanol, a-(aminomethyl)-, hydrochloride
9H-Fluorene-1-methanol, a-(aminomethyl)-, hydrochloride
CAS:110827-08-2
9H-Fluorene-1-methanol, a-(aminomethyl)-, hydrochloride
(1E)-1-(9H-fluoren-2-yl)ethanone oxime
(1E)-1-(9H-fluoren-2-yl)ethanone oxime
CAS:110827-07-1
(1E)-1-(9H-fluoren-2-yl)ethanone oxime
9H-Fluorene-1-methanamine, a-methyl-, hydrochloride
9H-Fluorene-1-methanamine, a-methyl-, hydrochloride
CAS:110827-06-0
9H-Fluorene-1-methanamine, a-methyl-, hydrochloride
9H-Fluorene-2-acetonitrile, a-[(trimethylsilyl)oxy]-
9H-Fluorene-2-acetonitrile, a-[(trimethylsilyl)oxy]-
CAS:110827-03-7
9H-Fluorene-2-acetonitrile, a-[(trimethylsilyl)oxy]-
9H-Fluorene-1-methanol, a-(aminomethyl)-
9H-Fluorene-1-methanol, a-(aminomethyl)-
CAS:110826-98-7
9H-Fluorene-1-methanol, a-(aminomethyl)-