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Bao Hu

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Organization: Zhejiang University of Technology
Department: College of Chemical Engineering and Materials Science
Title:
Catalyst-Free Preparation of 1,2,4,5-Tetrasubstituted Imidazoles from a Novel Unexpected Domino Reaction of 2-Azido Acrylates and Nitrones
Co-reporter:Bao Hu, Zhao Wang, Ning Ai, Jie Zheng, Xing-Hai Liu, Shang Shan, and Zhongwen Wang
Organic Letters 2011 Volume 13(Issue 24) pp:6362-6365
Publication Date(Web):November 9, 2011
DOI:10.1021/ol202650z
A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base.
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