Co-reporter:Kengo Akagawa;Kazuaki Kudo
Chemical Communications 2017 vol. 53(Issue 62) pp:8645-8648
Publication Date(Web):2017/08/01
DOI:10.1039/C7CC04033D
An iterative method for synthesizing polyketides was demonstrated, in which the chain elongation of a carboxylic acid was performed by decarboxylative dehydration condensation with a malonic acid half thioester. After transforming the resulting β-ketothioester into an appropriate form, the carboxylic acid functionality was regenerated for the next elongation step.
Co-reporter:Kengo Akagawa, Kazuaki Kudo
Tetrahedron Letters 2012 Volume 53(Issue 45) pp:5981-5983
Publication Date(Web):7 November 2012
DOI:10.1016/j.tetlet.2012.07.034
Co-reporter:Kengo Akagawa and Kazuaki Kudo
Chemical Communications 2017 - vol. 53(Issue 62) pp:NaN8648-8648
Publication Date(Web):2017/06/08
DOI:10.1039/C7CC04033D
An iterative method for synthesizing polyketides was demonstrated, in which the chain elongation of a carboxylic acid was performed by decarboxylative dehydration condensation with a malonic acid half thioester. After transforming the resulting β-ketothioester into an appropriate form, the carboxylic acid functionality was regenerated for the next elongation step.
![Benzonitrile, 4-[(1E)-3-oxo-1-propenyl]-](http://img.cochemist.com/ccimg/95800/95759-33-4.png)
![Benzonitrile, 4-[(1E)-3-oxo-1-propenyl]-](http://img.cochemist.com/ccimg/95800/95759-33-4_b.png)
![2-Propenal, 3-[3,5-bis(trifluoromethyl)phenyl]-, (E)-](http://img.cochemist.com/ccimg/95200/95123-62-9.png)
![2-Propenal, 3-[3,5-bis(trifluoromethyl)phenyl]-, (E)-](http://img.cochemist.com/ccimg/95200/95123-62-9_b.png)
![2-Propenal, 3-[4-(trifluoromethyl)phenyl]-, (2E)-](http://img.cochemist.com/ccimg/95200/95123-61-8.png)
![2-Propenal, 3-[4-(trifluoromethyl)phenyl]-, (2E)-](http://img.cochemist.com/ccimg/95200/95123-61-8_b.png)
