Peibiao Zhang

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Name: 章培标; PeiBiao Zhang

Organization: Graduate School of Chinese Academy of Sciences , China

Department: Changchun Institute of Applied Chemistry

Title: Researcher/Professor(PhD)

TOPICS

Material Chemistry

Chemicals
References

Preparation of porous nanocomposite scaffolds with honeycomb monolith structure by one phase solution freezedrying method

Co-reporter:Yang Xu;Duo Zhang 张舵;Zong-liang Wang;Zhan-tuan Gao

Chinese Journal of Polymer Science 2011 Volume 29( Issue 2) pp:215-224

Publication Date(Web):2011 March

DOI:10.1007/s10118-010-1015-5

Biodegradable porous nanocomposite scaffolds of poly(lactide-co-glycolide) (PLGA) and L-lactic acid (LAc) oligomer surface-grafted hydroxyapatite nanoparticles (op-HA) with a honeycomb monolith structure were fabricated with the single-phase solution freeze-drying method. The effects of different freezing temperatures on the properties of the scaffolds, such as microstructures, compressive strength, cell penetration and cell proliferation were studied. The highly porous and well interconnected scaffolds with a tunable pore structure were obtained. The effect of different freezing temperature (4°C, −20°C, −80°C and −196°C) was investigated in relation to the scaffold morphology, the porosity varied from 91.2% to 83.0% and the average pore diameter varied from (167.2 ± 62.6) μm to (11.9 ± 4.2) μm while the σ10 increased significantly. The cell proliferation were decreased and associated with the above-mentioned properties. Uniform distribution of op-HA particles and homogeneous roughness of pore wall surfaces were found in the 4°C frozen scaffold. The 4°C frozen scaffold exhibited better cell penetration and increased cell proliferation because of its larger pore size, higher porosity and interconnection. The microstructures described here provide a new approach for the design and fabrication of op-HA/PLGA based scaffold materials with potentially broad applicability for replacement of bone defects.

The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with l-lactic acid oligomer for bone repair

Co-reporter:Yang Cui, Yi Liu, Yi Cui, Xiabin Jing, Peibiao Zhang, Xuesi Chen

Acta Biomaterialia 2009 Volume 5(Issue 7) pp:2680-2692

Publication Date(Web):September 2009

DOI:10.1016/j.actbio.2009.03.024

Abstract

Nanohydroxyapatite (op-HA) surface-modified with l-lactic acid oligomer (LAc oligomer) was prepared by LAc oligomer grafted onto the hydroxyapatite (HA) surface. The nanocomposite of op-HA/PLGA with different op-HA contents of 5, 10, 20 and 40 wt.% in the composite was fabricated into three-dimensional scaffolds by the melt-molding and particulate leaching methods. PLGA and the nanocomposite of HA/PLGA with 10 wt.% of ungrafted hydroxyapatite were used as the controls. The scaffolds were highly porous with evenly distributed and interconnected pore structures, and the porosity was around 90%. Besides the macropores of 100–300 μm created by the leaching of NaCl particles, the micropores (1–50 μm) in the pore walls increased with increasing content of op-HA in the composites of op-HA/PLGA. The op-HA particles could disperse more uniformly than those of pure HA in PLGA matrix. The 20 wt.% op-HA/PLGA sample exhibited the maximum mechanical strength, including bending strength (4.14 MPa) and compressive strength (2.31 MPa). The cell viability and the areas of the attached osteoblasts on the films of 10 wt.% op-HA/PLGA and 20 wt.% op-HA/PLGA were evidently higher than those on the other composites. For the animal test, there was rapid healing in the defects treated with 10 and 20 wt.% op-HA/PLGA, where bridging by a large bony callus was observed at 24 weeks post-surgery. There was non-union of radius defects implanted with PLGA and in the untreated group. This was verified by the Masson’s trichrome staining photomicrographs of histological analysis. All the data extrapolated that the composite with 10 and 20 wt.% op-HA exhibited better comprehensive properties and were the optimal composites for bone repairing.

Preparation of Mesoporous Nano-Hydroxyapatite Using a Surfactant Template Method for Protein Delivery

Co-reporter:Xiaodong Wu, Xiaofeng Song, Dongsong Li, Jianguo Liu, ... Xuesi Chen

Journal of Bionic Engineering (June 2012) Volume 9(Issue 2) pp:224-233

Publication Date(Web):1 June 2012

DOI:10.1016/S1672-6529(11)60105-4

Mesoporous nano-hydroxyapatite (n-HA) has gained more and more attention as drug storage and release hosts. The aim of this study is to observe the effect of the ratio of surfactant to the theoretical yield of HA on the mesoporous n-HA, then to reveal the effect of the mesoporous nanostructure on protein delivery. The mesoporous n-HA was synthesized using the wet precipitation in the presence of cetyltrimethylammonium bromide (CTAB) at ambient temperature and normal atmospheric pressure. The morphology, size, crystalline phase, chemical composition and textural characteristics of the product were well characterized by X-ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and N2 adsorption/desorption, respectively. The protein adsorption/release studies were also carried out by using Bovine Serum Albumin (BSA) as a model protein. The results reveal that the mesoporous n-HA synthesized with CTAB exhibits high pure phase, low crystallinity and the typical characteristics of the mesostructure. The BSA loading increases with the specific surface area and the pore volume of n-HA, and the release rates of BSA are different due to their different pore sizes and pore structures. n-HA synthesized with 0.5% CTAB has the highest BSA loading and the slowest release rate because of its highest surface area and smaller pore size. These mesoporous n-HA materials demonstrate a potential application in the field of protein delivery due to their bioactive, biocompatible and mesoporous properties.