Complete protection of sodium valproate from humidity was successfully accomplished by intercalation into a hydrotalcite-like compound. The obtained hybrid of sodium valproate and the hydrotalcite-like compound was stable and not at all hygroscopic. Even under a relative humidity of 97%, the adsorbed amount of water was less than 0.5%. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:46–49, 2009
The intercalation of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), which is a drug for osteoporosis, in layered double hydroxide (LDH) was examined with the goal of developing a novel drug delivery system (DDS) of HEDP. To prevent side reactions, the intercalation reaction was carried out at 0°C, and at pH 4–6. The uptake of HEDP was determined as 3.5 mmol g−1 of LDH, and the interlayer distance increased from 7.8 to 13 Å. The HEDP-release profiles into K2CO3 aqueous solution and into various buffer solutions were also examined. © 2003 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 92:2419–2426, 2003
