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Sean Kerwin

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Organization: The University of Texas at Austin
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A concise synthesis of rooperol and related 1,5-diarylpent-1-en-4-ynes
Co-reporter:Sean M. Kerwin, Jonathan Cha
Tetrahedron Letters 2014 Volume 55(Issue 1) pp:137-141
Publication Date(Web):1 January 2014
DOI:10.1016/j.tetlet.2013.10.138
Two powerful strategies: rapid construction of allylic alkynoates via cyclopropenium ion chemistry and mild, palladium-catalyzed decarboxylative coupling were employed in a concise, 5-steps synthesis of the natural product rooperol. The overall approach allows the preparation of rooperol analogs in as few as 3 steps.
A Fluorescence-Based Assay for p38 Recruitment Site Binders: Identification of Rooperol as a Novel p38 Kinase Inhibitor
Co-reporter:Dr. Jing Li;Dr. Tamer S. Kaoud;Jake LeVieux;Brad Gilbreath;Dr. Swapna Moharana; Kevin N. Dalby; Sean M. Kerwin
ChemBioChem 2013 Volume 14( Issue 1) pp:66-71
Publication Date(Web):
DOI:10.1002/cbic.201200529
G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay
Co-reporter:Michelle Schoonover, Sean M. Kerwin
Bioorganic & Medicinal Chemistry 2012 20(24) pp: 6904-6918
Publication Date(Web):
DOI:10.1016/j.bmc.2012.10.017
1-(2-CHLOROPYRIMIDIN-4-YL)PYRROLIDIN-3-OL
1-(2-CHLOROPYRIMIDIN-4-YL)PYRROLIDIN-3-OL
CAS:130552-90-8
1-(2-CHLOROPYRIMIDIN-4-YL)PYRROLIDIN-3-OL
3-(3,4-dihydroxyphenyl)-n-(2-phenylethyl)prop-2-enamide
3-(3,4-dihydroxyphenyl)-n-(2-phenylethyl)prop-2-enamide
CAS:105955-01-9
3-(3,4-dihydroxyphenyl)-n-(2-phenylethyl)prop-2-enamide